Pharmacodynamic lincomycin bụ ọgwụ nje lincoamine, bụ onye na-ahụ maka bacteriostatic, nje nwere mmetụta na-agụnye staphylococcus aureus (gụnyere eriri na-eguzogide penicillin), streptococcus, pneumococcus, bacillus anthracis, erysipelas suis, ụfọdụ mycoplasma (mycoplasma suis na pneuoplasma, mycoplasma suis pneumonia). mycoplasmasuis synovialis), leptospirosis na anaerobic bacteria (dị ka clostridium difficile, clostridium tetanus, clostridium percapsulatus na ọtụtụ actinomyces). Ọ na-emekarị na mpaghara 50s nke ribosome nje bacteria, ma na-arụ ọrụ nje bacteria site na igbochi ndọtị nke yinye peptide na-emetụta njikọ protein.
Mmụba ahụ dị ngwa ngwa mgbe ịgbanye ọgwụ mgbochi intramuscular, yana otu ntụtụ intramuscular nke 11mg / kg n'ime ezì na ntinye ọbara kacha elu nke 6.25μg / ml. Ọnụego njikọ protein plasma bụ 57% - 72%. A na-ekesa ya n'ọtụtụ ebe na vivo, na-egosi oke nkesa nke 2.8 l / kg na ezì. A na-ekesa ya n'ọtụtụ mmiri dị iche iche nke anụ ahụ na anụ ahụ (gụnyere ọkpụkpụ), n'etiti nke imeju na akụrụ bụ nke kachasị elu, na ntinye nke ọgwụ anụ ahụ dị ọtụtụ ugboro karịa nke serum n'otu oge ahụ. Ọ nwere ike ịbanye na placenta, ma ọ dịghị mfe ịbanye n'ime ihe mgbochi ụbụrụ nke ọbara, ọ na-esikwa ike iru ntinye ọgwụ dị irè na mmiri cerebrospinal mgbe mbufụt pụtara. Enwere ike kesaa ya na mmiri ara ehi, na itinye uche na mmiri ara ehi bụ otu ihe ahụ na plasma. Akụkụ nke ọgwụ ahụ bụ metabolized na imeju, a na-ewepụkwa ụdị ọgwụ ahụ na metabolites ya site na bile, mmamịrị na mmiri ara ehi. Mpụpụ na stool nwere ike igbu oge ruo ọtụtụ ụbọchị, yabụ na ọ nwere mmetụta mgbochi na microorganisms nwere mmetụta nke eriri afọ.
1. Mgbe ejikọtara ya na gentamicin, ọ nwere mmetụta synergistic na gram-positive bacteria dị ka staphylococcus na streptococcus.
2. Mgbe ejikọtara ya na aminoglycosides na polypeptide ọgwụ nje, ọ nwere ike ịkwalite mmetụta mgbochi na nkwụsị nke neuromuscular. Ejikọtara ya na erythromycin nwere mmetụta mgbochi, n'ihi na ebe a na-eme ihe bụ otu ihe ahụ, erythromycin nwekwara njikọ siri ike na mpaghara 50s nke ribosomes nje karịa ngwaahịa a.
3. E kwesịghị ijikọ ya na ọgwụ mgbochi afọ ọsịsa nke na-egbochi peristalsis intestinal ma nwee ụrọ ọcha. 4. Enweghị ndakọrịta na kanamycin, neomycin, wdg.
Ọgwụ nje lincoamine. Maka ọrịa nje bacteria gram-positive, a pụkwara iji ya mee ihe maka treponemosis na mycoplasma na ọrịa ndị ọzọ.
Intramuscular injection: Otu dose, 0.0165 ~ 0.033ml kwa 1kg arọ ahụ maka ịnyịnya na ehi, 0.033ml maka atụrụ na ezi, otu ugboro n'ụbọchị; 0.033ml maka nkịta na nwamba, ugboro abụọ n'ụbọchị, maka 3 ruo 5 ụbọchị.
Intramuscular injection nwere ike ịkpata afọ ọsịsa na-adịru nwa oge ma ọ bụ stool dị nro. Ọ bụ ezie na ọ dị ụkọ, ekwesịrị ịme ihe ndị dị mkpa iji gbochie akpịrị ịkpọ nkụ ma ọ bụrụ na ha emee.
