10% Iron Dextran Injection

Pharmacodynamic ígwè bụ isi akụrụngwa nke hemoglobin na myoglobin. Hemoglobin bụ isi ihe na-ebu oxygen na sel ọbara uhie. Myoglobin bụ ebe mkpụrụ ndụ akwara na-echekwa oxygen iji nyere aka nye ya akwara n'oge mmega ahụ. Ọtụtụ n'ime enzymes na ihe ndị metụtara na tricarboxylic acid okirikiri nwere ígwè ma ọ bụ ọrụ naanị na ọnụnọ ígwè. Ya mere, na mgbakwunye na njikọ nke hemoglobin accelerated, ihe mgbaàmà ndị metụtara ụkọ ígwè anụ ahụ na mbelata ọrụ nke enzymes nwere ígwè, dị ka nkwụghachi azụ, mmebi omume, na adịghị ike anụ ahụ, nwere ike iji nwayọọ nwayọọ dozie ya mgbe mgbatị ígwè na-arụ ọrụ n'ime anụmanụ ndị na-adịghị ike. Pharmacokinetic ígwè maka ịgba ọgwụ na-etinye obi gị dum ngwa ngwa karịa ígwè ọnụ; mgbe ịgbanye ígwè dextran intramuscular n'ime ahụ, ntinye ọbara ruru n'ogo ya na awa 24-48, na molecule ya buru ibu. Ọ bụ arịa lymphatic na-etinye ya n'ahụ wee bufee ya n'ọbara, na ntinye ọbara na-abawanye nwayọọ nwayọọ; mgbe ịgbanye eriri afọ ma ọ bụ intramuscular n'ime ọbara na-ekesa, ọ bụ phagocytic ma mebie n'ime ígwè na dextran site na mononuclear phagocytic cell system. Mgbe absorption, iron ion na-oxidized ka ferric ion site ceruloplasmin n'ime ọbara, na mgbe ahụ na-ekekọta transferrin receptors, banye cell n'ụdị pinocytosis maka hematopoietic cell, ma ọ bụ gbakọta n'ụdị ferritin ma ọ bụ hemosiderin na imeju, splin, ụmị ọkpụkpụ na ndị ọzọ mononuclear phagocytic cell usoro. Ọnụ ọgụgụ njikọ protein dị elu na hemoglobin, mana ọ dị ntakịrị na myoglobin, enzymes na protein na-ebufe ígwè, yana ferritin ma ọ bụ hemosiderin dị ntakịrị.