Pharmacodynamics enrofloxacin bụ ọgwụ nje na-egbu egbu maka anụmanụ fluoroquinolone. Ọ na-enwe mmetụta dị mma na escherichia coli, salmonella, klebsiella, brucella, pasteurella, actinobacillus pleuropneumoniae, erysipelas, proteus, serratia marcescens, corynebacterium pyogenes, portococcus septicus, staphylococcus aureus, mycoplasma na-adịghị ike na-enwe mmetụta na-adịghị ike. aeruginosa na streptococcus, yana mmetụta adịghị ike na nje bacteria anaerobic. Ọ nwere mmetụta doro anya post-antibacterial na nje bacteria nwere mmetụta. Usoro nje bacteria nke ngwaahịa a bụ igbochi nje dna rotation enzyme, na-egbochi mmegharị DNA nke nje bacteria, ntụgharị na nrụzi nchikota, nje bacteria enweghị ike itolite na ịmụpụta nke ọma wee nwụọ.
Pharmacokinetics nnabata intramuscular nke ngwaahịa a bụ ngwa ngwa na zuru oke, yana bioavailability nke 91.9% na ezì yana 82% na ehi mmiri ara ehi. A na-ekesa ya n'ọtụtụ ebe n'ime anụmanụ ma nwee ike ịbanye n'anụ ahụ na mmiri ahụ nke ọma, ma e wezụga mmiri mmiri cerebrospinal, ntinye ọgwụ na ihe fọrọ nke nta ka ọ bụrụ anụ ahụ niile dị elu karịa na plasma. Metabolism nke imeju na-abụkarị imepụta ciprofloxacin site na iwepu ethyl nke mgbanaka 7-piperazine, na-esote oxidation na njikọ glucuronic acid. A na-ewepụ ya nke ọma site na akụrụ (site na renal tubule secretion na glomerular filtration), na 15% ruo 50% na-esi na mmamịrị n'ụdị mbụ ya pụta. Mwepụ ọkara ndụ dịgasị iche iche na ụdị dị iche iche na ụzọ nchịkwa dị iche iche. Mwepụ ọkara ndụ mgbe ịgba ọgwụ intramuscular gasịrị bụ awa 5.9 na ehi, awa 9.9 na ịnyịnya, awa 1.5 ruo 4.5 na atụrụ, na awa 4.6 na ezì.
1. Ngwaahịa a nwere mmetụta synergistic mgbe ejiri ya na aminoglycoside ma ọ bụ penicillin sara mbara.
2. ion ígwè dị arọ dị ka ca2+, mg2+, fe3+ na al3+ canchelate na ngwaahịa a ma na-emetụta absorption.
3. Mgbe ejikọtara ya na theophylline na caffeine, ọ nwere ike ibelata ọnụego njikọ nke protein plasma, na-abawanye ụba nke theophylline na caffeine n'ime ọbara, na ọbụna pụta ìhè theophylline nsi.
4. Ngwaahịa a nwere mmetụta nke inhibiting imeju ọgwụ enzymes, nke nwere ike ibelata mkpochapụ ọnụego nke ọgwụ tumadi metabolized na imeju na-amụba ọbara ọgwụ ịta.
Fluoroquinolone ọgwụ nje. A na-eji ya maka ọrịa nje bacteria na anụ ọkụkọ na ọrịa mycoplasma.
Intramuscular injection: Otu dose, 0.025ml kwa 1kg arọ anụ ehi, atụrụ na ezi; 0.025 ~ 0.05ml maka nkịta, nwamba na oke bekee. Jiri 1 ruo 2 ugboro n'ụbọchị maka 2 ruo 3 ụbọchị.
1. Cartilage degeneration na ụmụ anụmanụ na-eto eto, na-emetụta ọkpụkpụ ọkpụkpụ na-eme ka ngwọrọ na mgbu.
2. Mmeghachi omume nke usoro nri digestive gụnyere vomiting, ọnwụ nke agụụ, afọ ọsịsa na n'oge na-adịghị anya.
3. Mmeghachi omume akpụkpọ ahụ gụnyere erythema, itching, urticaria na photosensitivity.
4. Mmeghachi omume nfụkasị ahụ, ataxia, ọdịdọ na-ahụ na nkịta na nwamba.
1. Ọ nwere mmetụta na-akpali akpali na sistemụ etiti, na-ebute ọdịdọ akwụkwụ, na ekwesịrị iji nlezianya mee ihe na nkịta epileptic.
2. E kwesịrị iji nlezianya jiri anụ anụ na anụmanụ na-arụ ọrụ akụrụ na-adịghị mma, nke nwere ike ịkpata mamịrị kristal mgbe ụfọdụ.
3. Ngwaahịa a adịghị mma maka ịnyịnya. Intramuscular injections bụ nwa oge iwe iwe.
4. E kwesịghị iji ngwaahịa a na nkịta tupu izu 8.
5. Ụdị ọgwụ na-eguzogide ọgwụ nke ngwaahịa a na-abawanye ma ghara iji ya mee ihe na usoro ọgwụgwọ ruo ogologo oge.
